Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures

Prions cause neurodegeneration in vivo, yet prion-infected cultured cells do not show cytotoxicity. This has hampered mechanistic studies of prion-induced neurodegeneration. Here we report that prion-infected cultured organotypic cerebellar slices (COCS) experienced progressive spongiform neurodegen...

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Detalhes bibliográficos
Main Authors: Falsig, Jeppe, Sonati, Tiziana, Herrmann, Uli S., Saban, Dino, Li, Bei, Arroyo, Karina, Ballmer, Boris, Liberski, Pawel P., Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486912/
https://ncbi.nlm.nih.gov/pubmed/23133383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002985
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