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Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures
Prions cause neurodegeneration in vivo, yet prion-infected cultured cells do not show cytotoxicity. This has hampered mechanistic studies of prion-induced neurodegeneration. Here we report that prion-infected cultured organotypic cerebellar slices (COCS) experienced progressive spongiform neurodegen...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3486912/ https://ncbi.nlm.nih.gov/pubmed/23133383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002985 |
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