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Differential Toxicity of Antibodies to the Prion Protein

Antibodies against the prion protein PrP(C) can antagonize prion replication and neuroinvasion, and therefore hold promise as possible therapeutics against prion diseases. However, the safety profile of such antibodies is controversial. It was originally reported that the monoclonal antibody D13 exh...

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Podrobná bibliografie
Vydáno v:PLoS Pathog
Hlavní autoři: Reimann, Regina R., Sonati, Tiziana, Hornemann, Simone, Herrmann, Uli S., Arand, Michael, Hawke, Simon, Aguzzi, Adriano
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731068/
https://ncbi.nlm.nih.gov/pubmed/26821311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005401
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