Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

Resistance to proteolytic digestion has long been considered a defining trait of prions in tissues of organisms suffering from transmissible spongiform encephalopathies. Detection of proteinase K-resistant prion protein (PrP(Sc)) still represents the diagnostic gold standard for prion diseases in hu...

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Udgivet i:PLoS One
Main Authors: Leske, Henning, Hornemann, Simone, Herrmann, Uli Simon, Zhu, Caihong, Dametto, Paolo, Li, Bei, Laferriere, Florent, Polymenidou, Magdalini, Pelczar, Pawel, Reimann, Regina Rose, Schwarz, Petra, Rushing, Elisabeth Jane, Wüthrich, Kurt, Aguzzi, Adriano
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313174/
https://ncbi.nlm.nih.gov/pubmed/28207746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170503
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