Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

The discovery that prion protein can misfold into a pathological conformation that encodes structural information capable of both propagation and inducing severe neuropathology has revolutionized our understanding of neurodegenerative disease. Many neurodegenerative diseases with a protein misfoldin...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: McAlary, Luke, Plotkin, Steven S., Yerbury, Justin J., Cashman, Neil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838634/
https://ncbi.nlm.nih.gov/pubmed/31736708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00262
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