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Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

Dissociation of superoxide dismutase 1 dimers is enhanced by glutathionylation, although the dissociation constants reported to date are imprecise. We have quantified the discreet dissociation constants for wild-type superoxide dismutase 1 and six naturally occurring sequence variants, in their unmo...

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Bibliografische gegevens
Hoofdauteurs: McAlary, Luke, Yerbury, Justin J., Aquilina, J. Andrew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834562/
https://ncbi.nlm.nih.gov/pubmed/24253732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03275
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