EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming

Acquired and intrinsic resistance to receptor tyrosine kinase inhibitors (RTKi) represent a major hurdle in improving the management of clear cell renal cell carcinoma (ccRCC). Recent reports suggest that drug resistance is driven by tumor adaptation via epigenetic mechanisms that activate alternati...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Adelaiye-Ogala, Remi, Budka, Justin, Damayanti, Nur P., Arrington, Justine, Ferris, Mary, Hsu, Chuan-Chih, Chintala, Sreenivasulu, Orillion, Ashley, Miles, Kiersten Marie, Shen, Li, Elbanna, May, Ciamporcero, Eric, Arisa, Sreevani, Pettazzoni, Piergiorgio, Draetta, Giulio F., Seshadri, Mukund, Hancock, Bradley, Radovich, Milan, Kota, Janaiah, Buck, Michael, Keilhack, Heike, McCarthy, Brian P., Persohn, Scott A., Territo, Paul R., Zang, Yong, Irudayaraj, Joseph, Tao, W. Andy, Hollenhorst, Peter, Pili, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712262/
https://ncbi.nlm.nih.gov/pubmed/28978636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0899
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