Entinostat neutralizes myeloid derived suppressor cells and enhances the antitumor effect of PD-1 inhibition in murine models of lung and renal cell carcinoma

PURPOSE: Recent advances in immunotherapy highlight the antitumor effects of immune- checkpoint inhibition despite a relatively limited subset of patients receiving clinical benefit. The selective class I histone deacetylase inhibitor (HDACi) entinostat has been reported to have immunomodulatory act...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Orillion, Ashley, Hashimoto, Ayumi, Damayanti, Nur, Shen, Li, Adelaiye-Ogala, Remi, Arisa, Sreevani, Chintala, Sreenivasulu, Ordentlich, Peter, Kao, Chingai, Elzey, Bennett, Gabrilovich, Dmitry, Pili, Roberto
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723438/
https://ncbi.nlm.nih.gov/pubmed/28698201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0741
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