Therapeutic targeting of TFE3/IRS-1/PI3K/mTOR axis in translocation renal cell carcinoma

PURPOSE: Translocation renal cell carcinoma (tRCC) represents a rare subtype of kidney cancer associated with various TFE3, TFEB, or MITF gene fusions that is not responsive to standard treatments for RCC. Therefore, the identification of new therapeutic targets represents an unmet need for this dis...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Damayanti, Nur P., Budka, Justin A., Khella, Heba W.Z, Ferris, Mary W., Ku, Sheng Yu, Kauffman, Eric, Wood, Anthony C., Ahmed, Khunsha, Chintala, Venkata Nithinsai, Adelaiye-Ogala, Remi, Elbanna, May, Orillion, Ashley, Chintala, Sreenivasulu, Kao, Chinghai, Linehan, W. Marston, Yousef, George M, Hollenhorst, Peter C., Pili, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279468/
https://ncbi.nlm.nih.gov/pubmed/30061365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0269
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