Dietary protein restriction reprograms tumor associated macrophages and enhances immunotherapy

PURPOSE: Diet and healthy weight are established means of reducing cancer incidence and mortality. However, the impact of diet modifications on the tumor microenvironment (TME) and antitumor immunity are not well-defined. Immunosuppressive tumor-associated macrophages (TAMs) are associated with poor...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Orillion, Ashley, Damayanti, Nur, Shen, Li, Adelaiye-Ogala, Remi, Affronti, Hayley, Elbanna, May, Chintala, Sreenivasulu, Ciesielski, Michael, Fontana, Luigi, Kao, Chinghai, Elzey, Bennett D., Ratliff, Timothy L., Nelson, David E., Smiraglia, Dominic, Abrams, Scott I., Pili, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6455918/
https://ncbi.nlm.nih.gov/pubmed/30190370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0980
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