Dual inhibition of angiopoietin-TIE2 and MET alters the tumor microenvironment and prolongs survival in a metastatic model of renal cell carcinoma

Receptor tyrosine kinase inhibitors have shown clinical benefit in clear cell renal cell carcinoma (ccRCC) but novel therapeutic strategies are needed. The angiopoietin/Tie2 and MET pathways have been implicated in tumor angiogenesis, metastases, and macrophage infiltration. In our study, we used tr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Elbanna, May, Orillion, Ashley R., Damayanti, Nur P., Adelaiye-Ogala, Remi, Shen, Li, Miles, Kristen Marie, Chintala, Sreenivasulu, Ciamporcero, Eric, Ramikrishnan, Swathi, Ku, Sheng-yu, Rex, Karen, Caenepeel, Sean, Coxon, Angela, Pili, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002017/
https://ncbi.nlm.nih.gov/pubmed/31582532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1202
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados