Dual inhibition of angiopoietin-TIE2 and MET alters the tumor microenvironment and prolongs survival in a metastatic model of renal cell carcinoma

Receptor tyrosine kinase inhibitors have shown clinical benefit in clear cell renal cell carcinoma (ccRCC) but novel therapeutic strategies are needed. The angiopoietin/Tie2 and MET pathways have been implicated in tumor angiogenesis, metastases, and macrophage infiltration. In our study, we used tr...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Elbanna, May, Orillion, Ashley R., Damayanti, Nur P., Adelaiye-Ogala, Remi, Shen, Li, Miles, Kristen Marie, Chintala, Sreenivasulu, Ciamporcero, Eric, Ramikrishnan, Swathi, Ku, Sheng-yu, Rex, Karen, Caenepeel, Sean, Coxon, Angela, Pili, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002017/
https://ncbi.nlm.nih.gov/pubmed/31582532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1202
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