Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion

Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting states. However, the mechanisms responsible for the regulation of pancreatic α cell mass and function are not completely understood. In the current study, we identified mTOR complex 1 (mTORC1) as a major regu...

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Vydáno v:J Clin Invest
Hlavní autoři: Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Chase, Jennifer, Dai, Xiao-Qing, Cummings, Kelsey, Gimeno, Jennifer, Dean, Danielle, Powers, Alvin C., Gittes, George K., Rüegg, Markus A., Hall, Michael N., MacDonald, Patrick E., Bernal-Mizrachi, Ernesto
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707167/
https://ncbi.nlm.nih.gov/pubmed/29106387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90004
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