Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic diseases, including type 2 diabetes. Here we show that β-cell-specific loss of mTORC1 causes diabetes and β-cell failure due to defects in proliferation, autophagy, apoptosis and insulin secretion by using mice with...

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Publicado no:Nat Commun
Main Authors: Blandino-Rosano, Manuel, Barbaresso, Rebecca, Jimenez-Palomares, Margarita, Bozadjieva, Nadejda, Werneck-de-Castro, Joao Pedro, Hatanaka, Masayuki, Mirmira, Raghavendra G., Sonenberg, Nahum, Liu, Ming, Rüegg, Markus A., Hall, Michael N., Bernal-Mizrachi, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510183/
https://ncbi.nlm.nih.gov/pubmed/28699639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16014
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