4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass

The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that...

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Publicat a:Diabetes
Autors principals: Blandino-Rosano, Manuel, Scheys, Joshua O., Jimenez-Palomares, Margarita, Barbaresso, Rebecca, Bender, Aaron S., Yanagiya, Akiko, Liu, Ming, Rui, Liangyou, Sonenberg, Nahum, Bernal-Mizrachi, Ernesto
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2016
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955981/
https://ncbi.nlm.nih.gov/pubmed/27217487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1443
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