Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass

Regulation of glucose homeostasis by insulin depends on β-cell growth and function. Nutrients and growth factor stimuli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two complexes, mTORC1 and mTORC2. To understand the functional relevance of mTOR enzyma...

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Vydáno v:Diabetes
Hlavní autoři: Alejandro, Emilyn U., Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Wasan, Michelle Ann, Elghazi, Lynda, Vadrevu, Suryakiran, Satin, Leslie, Bernal-Mizrachi, Ernesto
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2017
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521866/
https://ncbi.nlm.nih.gov/pubmed/28546423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1349
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