Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass

Regulation of glucose homeostasis by insulin depends on β-cell growth and function. Nutrients and growth factor stimuli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two complexes, mTORC1 and mTORC2. To understand the functional relevance of mTOR enzyma...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Alejandro, Emilyn U., Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Wasan, Michelle Ann, Elghazi, Lynda, Vadrevu, Suryakiran, Satin, Leslie, Bernal-Mizrachi, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521866/
https://ncbi.nlm.nih.gov/pubmed/28546423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1349
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