Disruption of O-linked N-acetylglucosamine signaling induces ER stress and β-cell failure

Nutrient levels dictate the activity of O-linked N-acetylglucosamine Transferase (OGT) to regulate O-GlcNAcylation, a post-translational modification mechanism to “fine-tune” intracellular signaling and metabolic status. However, the requirement of O-GlcNAcylation for maintaining glucose homeostasis...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Alejandro, Emilyn U., Bozadjieva, Nadejda, Kumusoglu, Doga, Abdulhamid, Sarah, Levine, Hannah, Haataja, Leena, Vadrevu, Suryakiran, Satin, Leslie S., Arvan, Peter, Bernal-Mizrachi, Ernesto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839001/
https://ncbi.nlm.nih.gov/pubmed/26673325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.020
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