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Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring
Pancreatic β-cells are exquisitely sensitive to developmental nutrient stressors, and alterations in nutrient sensing pathways may underlie changes observed in these models. Here we developed a mouse model of in utero exposure to the anti-diabetic agent metformin. We have previously shown that this...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893596/ https://ncbi.nlm.nih.gov/pubmed/29636523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23965-4 |
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