Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring

Pancreatic β-cells are exquisitely sensitive to developmental nutrient stressors, and alterations in nutrient sensing pathways may underlie changes observed in these models. Here we developed a mouse model of in utero exposure to the anti-diabetic agent metformin. We have previously shown that this...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gregg, Brigid E., Botezatu, Nathalie, Brill, Joshua D., Hafner, Hannah, Vadrevu, Suryakiran, Satin, Leslie S., Alejandro, Emilyn U., Bernal-Mizrachi, Ernesto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893596/
https://ncbi.nlm.nih.gov/pubmed/29636523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23965-4
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