Maternal diet–induced microRNAs and mTOR underlie β cell dysfunction in offspring

A maternal diet that is low in protein increases the susceptibility of offspring to type 2 diabetes by inducing long-term alterations in β cell mass and function. Nutrients and growth factor signaling converge through mTOR, suggesting that this pathway participates in β cell programming during fetal...

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Huvudupphovsmän: Alejandro, Emilyn U., Gregg, Brigid, Wallen, Taylor, Kumusoglu, Doga, Meister, Daniel, Chen, Angela, Merrins, Matthew J., Satin, Leslie S., Liu, Ming, Arvan, Peter, Bernal-Mizrachi, Ernesto
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2014
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Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191023/
https://ncbi.nlm.nih.gov/pubmed/25180600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74237
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