RNA targeting with CRISPR-Cas13a

RNA plays important and diverse roles in biology, but molecular tools to manipulate and measure RNA are limited. For example, RNA interference (RNAi)(1-3) can efficiently knockdown RNAs, but it is prone to off-target effects(4), and visualizing RNAs typically relies on the introduction of exogenous...

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Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Abudayyeh, Omar O., Gootenberg, Jonathan S., Essletzbichler, Patrick, Han, Shuo, Joung, Julia, Belanto, Joseph J., Verdine, Vanessa, Cox, David B.T., Kellner, Max J., Regev, Aviv, Lander, Eric S., Voytas, Daniel F., Ting, Alice Y., Zhang, Feng
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706658/
https://ncbi.nlm.nih.gov/pubmed/28976959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24049
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