Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice

BACKGROUND: (Over-)expression of arginase may limit local availability of arginine for nitric oxide synthesis. We investigated the significance of arginase1 (ARG1) for the development of airway hyperresponsiveness (AHR) and lung inflammation in female mice with ovalbumin (OVA)-induced allergic asthm...

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Vydáno v:BMC Pulm Med
Hlavní autoři: Cloots, Roy H. E., Sankaranarayanan, Selvakumari, Poynter, Matthew E., Terwindt, Els, van Dijk, Paul, Lamers, Wouter H., Eleonore Köhler, S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706166/
https://ncbi.nlm.nih.gov/pubmed/29183288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-017-0490-7
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