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Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation

Numerous mutations have been observed in the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase (RTK) in both germline and sporadic neuroblastoma. Here, we have investigated the Y1278S mutation, observed in four patient cases, and its potential importance in the activation of the full length...

詳細記述

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書誌詳細
出版年:Cancers (Basel)
主要な著者: Guan, Jikui, Yamazaki, Yasuo, Chand, Damini, van Dijk, Jesper R., Ruuth, Kristina, Palmer, Ruth H., Hallberg, Bengt
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704167/
https://ncbi.nlm.nih.gov/pubmed/29084134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers9110149
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