Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor which has been implicated in numerous solid and hematologic cancers. ALK mutations are reported in about 5-7% of neuroblastoma cases but the ALK-positive percentage increases significantly in the relapsed patient population. Crizotinib,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Siaw, Joachim T., Wan, Haiying, Pfeifer, Kathrin, Rivera, Victor M., Guan, Jikui, Palmer, Ruth H., Hallberg, Bengt
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045374/
https://ncbi.nlm.nih.gov/pubmed/27049722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8508
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