The Neuroblastoma ALK(I1250T) Mutation Is a Kinase-Dead RTK In Vitro and In Vivo

Activating mutations in the kinase domain of anaplastic lymphoma kinase (ALK) have recently been shown to be an important determinant in the genetics of the childhood tumor neuroblastoma. Here we discuss an in-depth analysis of one of the reported gain-of-function ALK mutations—ALK(I1250T)—identifie...

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Detalhes bibliográficos
Main Authors: Schönherr, Christina, Ruuth, Kristina, Eriksson, Therese, Yamazaki, Yasuo, Ottmann, Christian, Combaret, Valerie, Vigny, Marc, Kamaraj, Sattu, Palmer, Ruth H, Hallberg, Bengt
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140014/
https://ncbi.nlm.nih.gov/pubmed/21804922
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