The Neuroblastoma ALK(I1250T) Mutation Is a Kinase-Dead RTK In Vitro and In Vivo

Activating mutations in the kinase domain of anaplastic lymphoma kinase (ALK) have recently been shown to be an important determinant in the genetics of the childhood tumor neuroblastoma. Here we discuss an in-depth analysis of one of the reported gain-of-function ALK mutations—ALK(I1250T)—identifie...

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Détails bibliographiques
Auteurs principaux: Schönherr, Christina, Ruuth, Kristina, Eriksson, Therese, Yamazaki, Yasuo, Ottmann, Christian, Combaret, Valerie, Vigny, Marc, Kamaraj, Sattu, Palmer, Ruth H, Hallberg, Bengt
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press Inc. 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140014/
https://ncbi.nlm.nih.gov/pubmed/21804922
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