Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells

Activation of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase is a key oncogenic mechanism in a growing number of tumor types. In the majority of cases, ALK is activated by fusion with a dimerizing partner protein as a result of chromosomal translocation events, most studied in the cas...

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Autors principals: Sattu, Kamaraj, Hochgräfe, Falko, Wu, Jianmin, Umapathy, Ganesh, Schönherr, Christina, Ruuth, Kristina, Chand, Damini, Witek, Barbara, Fuchs, James, Li, Pui-Kai, Hugosson, Fredrik, Daly, Roger J, Palmer, Ruth H, Hallberg, Bengt
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
Matèries:
Special Issue
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892176/
https://ncbi.nlm.nih.gov/pubmed/23889739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12453
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