Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance

A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measur...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Nakatani, Yoshio, Opel-Reading, Helen K., Merker, Matthias, Machado, Diana, Andres, Sönke, Kumar, S. Siva, Moradigaravand, Danesh, Coll, Francesc, Perdigão, João, Portugal, Isabel, Schön, Thomas, Nair, Dina, Devi, K. R. Uma, Kohl, Thomas A., Beckert, Patrick, Clark, Taane G., Maphalala, Gugu, Khumalo, Derrick, Diel, Roland, Klaos, Kadri, Aung, Htin Lin, Cook, Gregory M., Parkhill, Julian, Peacock, Sharon J., Swaminathan, Soumya, Viveiros, Miguel, Niemann, Stefan, Krause, Kurt L., Köser, Claudio U.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2017
Onderwerpen:
Mechanisms of Resistance
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700341/
https://ncbi.nlm.nih.gov/pubmed/28971867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01575-17
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