Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance

A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measur...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Antimicrob Agents Chemother
المؤلفون الرئيسيون: Nakatani, Yoshio, Opel-Reading, Helen K., Merker, Matthias, Machado, Diana, Andres, Sönke, Kumar, S. Siva, Moradigaravand, Danesh, Coll, Francesc, Perdigão, João, Portugal, Isabel, Schön, Thomas, Nair, Dina, Devi, K. R. Uma, Kohl, Thomas A., Beckert, Patrick, Clark, Taane G., Maphalala, Gugu, Khumalo, Derrick, Diel, Roland, Klaos, Kadri, Aung, Htin Lin, Cook, Gregory M., Parkhill, Julian, Peacock, Sharon J., Swaminathan, Soumya, Viveiros, Miguel, Niemann, Stefan, Krause, Kurt L., Köser, Claudio U.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2017
الموضوعات:
Mechanisms of Resistance
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700341/
https://ncbi.nlm.nih.gov/pubmed/28971867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01575-17
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