Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance

A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measur...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Nakatani, Yoshio, Opel-Reading, Helen K., Merker, Matthias, Machado, Diana, Andres, Sönke, Kumar, S. Siva, Moradigaravand, Danesh, Coll, Francesc, Perdigão, João, Portugal, Isabel, Schön, Thomas, Nair, Dina, Devi, K. R. Uma, Kohl, Thomas A., Beckert, Patrick, Clark, Taane G., Maphalala, Gugu, Khumalo, Derrick, Diel, Roland, Klaos, Kadri, Aung, Htin Lin, Cook, Gregory M., Parkhill, Julian, Peacock, Sharon J., Swaminathan, Soumya, Viveiros, Miguel, Niemann, Stefan, Krause, Kurt L., Köser, Claudio U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700341/
https://ncbi.nlm.nih.gov/pubmed/28971867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01575-17
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