d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition

The broad-spectrum antibiotic d-cycloserine (DCS) is a key component of regimens used to treat multi- and extensively drug-resistant tuberculosis. DCS, a structural analogue of d-alanine, binds to and inactivates two essential enzymes involved in peptidoglycan biosynthesis, alanine racemase (Alr) an...

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Publicado en:Nat Chem Biol
Autores principales: de Chiara, Cesira, Homšak, Miha, Prosser, Gareth A., Douglas, Holly L., Garza-Garcia, Acely, Kelly, Geoff, Purkiss, Andrew G., Tate, Edward W., de Carvalho, Luiz Pedro S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246083/
https://ncbi.nlm.nih.gov/pubmed/32203411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0498-9
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