Učitavanje...
d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
The broad-spectrum antibiotic d-cycloserine (DCS) is a key component of regimens used to treat multi- and extensively drug-resistant tuberculosis. DCS, a structural analogue of d-alanine, binds to and inactivates two essential enzymes involved in peptidoglycan biosynthesis, alanine racemase (Alr) an...
Spremljeno u:
| Izdano u: | Nat Chem Biol |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7246083/ https://ncbi.nlm.nih.gov/pubmed/32203411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0498-9 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|