Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance

A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measur...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Nakatani, Yoshio, Opel-Reading, Helen K., Merker, Matthias, Machado, Diana, Andres, Sönke, Kumar, S. Siva, Moradigaravand, Danesh, Coll, Francesc, Perdigão, João, Portugal, Isabel, Schön, Thomas, Nair, Dina, Devi, K. R. Uma, Kohl, Thomas A., Beckert, Patrick, Clark, Taane G., Maphalala, Gugu, Khumalo, Derrick, Diel, Roland, Klaos, Kadri, Aung, Htin Lin, Cook, Gregory M., Parkhill, Julian, Peacock, Sharon J., Swaminathan, Soumya, Viveiros, Miguel, Niemann, Stefan, Krause, Kurt L., Köser, Claudio U.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700341/
https://ncbi.nlm.nih.gov/pubmed/28971867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01575-17
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