Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery. Historically, allostery in structured proteins has been interpreted in terms of propagated stru...

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Udgivet i:eLife
Main Authors: Li, Jing, White, Jordan T, Saavedra, Harry, Wrabl, James O, Motlagh, Hesam N, Liu, Kaixian, Sowers, James, Schroer, Trina A, Thompson, E Brad, Hilser, Vincent J
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697930/
https://ncbi.nlm.nih.gov/pubmed/29022880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30688
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