Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery. Historically, allostery in structured proteins has been interpreted in terms of propagated stru...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Li, Jing, White, Jordan T, Saavedra, Harry, Wrabl, James O, Motlagh, Hesam N, Liu, Kaixian, Sowers, James, Schroer, Trina A, Thompson, E Brad, Hilser, Vincent J
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Structural Biology and Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697930/
https://ncbi.nlm.nih.gov/pubmed/29022880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30688
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky