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Bone Marrow as a Hematopoietic Stem Cell Source for Gene Therapy in Sickle Cell Disease: Evidence from Rhesus and SCD Patients

Steady state bone marrow (BM) is the preferred hematopoietic stem cell (HSC) source for gene therapy in sickle cell disease (SCD) due to the recognized risk of vaso-occlusive crisis during granulocyte colony–stimulating factor mobilization. We previously established clinically relevant HSC gene tran...

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Détails bibliographiques
Publié dans:Hum Gene Ther Clin Dev
Auteurs principaux: Uchida, Naoya, Fujita, Atsushi, Hsieh, Matthew M., Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Donahue, Robert E., Tisdale, John F.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695729/
https://ncbi.nlm.nih.gov/pubmed/28447889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2017.029
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