High-efficiency Transduction of Rhesus Hematopoietic Repopulating Cells by a Modified HIV1-based Lentiviral Vector

Human immunodeficiency virus type 1 (HIV1) vectors poorly transduce rhesus hematopoietic cells due to species-specific restriction factors, including the tripartite motif-containing 5 isoformα (TRIM5α) which targets the HIV1 capsid. We previously developed a chimeric HIV1 (χHIV) vector system wherei...

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Autors principals: Uchida, Naoya, Hargrove, Phillip W., Lap, Coen J., Evans, Molly E., Phang, Oswald, Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Nguyen, Anh-Dao, Hsieh, Matthew M., Wolfsberg, Tyra G., Donahue, Robert E., Persons, Derek A., Tisdale, John F.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464651/
https://ncbi.nlm.nih.gov/pubmed/22871664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.159
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