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Granzyme B disrupts central metabolism and protein synthesis in bacteria to promote an immune cell death program
Human cytotoxic lymphocytes kill intracellular microbes. The cytotoxic granule granzyme proteases released by cytotoxic lymphocytes trigger oxidative bacterial death by disrupting electron transport, generating superoxide anion and inactivating bacterial oxidative defenses. However, they also cause...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693722/ https://ncbi.nlm.nih.gov/pubmed/29107333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.004 |
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