Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation

Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure. Here we demonstrate that pro...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Dang, Eric V., McDonald, Jeffrey G., Russell, David W., Cyster, Jason G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693620/
https://ncbi.nlm.nih.gov/pubmed/29033131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.029
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