Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulat...

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Bibliografiska uppgifter
I publikationen:Nat Microbiol
Huvudupphovsmän: Abrams, Michael E., Johnson, Kristen A., Perelman, Sofya S., Zhang, Li-shu, Endapally, Shreya, Mar, Katrina B., Thompson, Bonne M., McDonald, Jeffrey G., Schoggins, John W., Radhakrishnan, Arun, Alto, Neal M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442315/
https://ncbi.nlm.nih.gov/pubmed/32284563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0701-5
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