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25-hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
Type-I interferon (IFN) protects against viruses yet it also has a poorly understood suppressive influence on inflammation. Here we report that activated mouse macrophages lacking the IFN-stimulated gene, cholesterol 25-hydroxylase (Ch25h), and that are unable to produce the oxysterol 25-hydroxychol...
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| 出版年: | Science |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4289637/ https://ncbi.nlm.nih.gov/pubmed/25104388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254790 |
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