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25-hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

Type-I interferon (IFN) protects against viruses yet it also has a poorly understood suppressive influence on inflammation. Here we report that activated mouse macrophages lacking the IFN-stimulated gene, cholesterol 25-hydroxylase (Ch25h), and that are unable to produce the oxysterol 25-hydroxychol...

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Foilsithe in:Science
Main Authors: Reboldi, Andrea, Dang, Eric V., McDonald, Jeffrey G., Liang, Guosheng, Russell, David W., Cyster, Jason G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289637/
https://ncbi.nlm.nih.gov/pubmed/25104388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254790
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