25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection

Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of choleste...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Doms, Alexandra, Sanabria, Tatiana, Hansen, Jeanne N., Altan-Bonnet, Nihal, Holm, Geoffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146694/
https://ncbi.nlm.nih.gov/pubmed/29950420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01047-18
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