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Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation
Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure. Here we demonstrate that pro...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693620/ https://ncbi.nlm.nih.gov/pubmed/29033131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.029 |
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