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A Stereoselective [3+1] Ring Expansion for the Synthesis of Highly-Substituted Methylene Azetidines

The reaction of rhodium-bound carbenes with strained bicyclic methylene aziridines results in a formal [3+1] ring expansion to yield highly-substituted methylene azetidines with excellent regio-and stereoselectivity. The reaction appears to proceed through an ylide-type mechanism, where the unique s...

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書目詳細資料
發表在:Angew Chem Int Ed Engl
Main Authors: Schmid, Steven C., Guzei, Ilia A., Schomaker, Jennifer M.
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693379/
https://ncbi.nlm.nih.gov/pubmed/28834110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201705202
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