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Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides

The importance of N-heterocycles in drugs has stimulated diverse methods for their efficient syntheses. Methods that introduce significant stereochemical complexity are attractive for identifying new bioactive amine chemical space. Here, we report a [3 + 3] ring expansion of bicyclic aziridines and...

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Publicado en:Nat Commun
Main Authors: Eshon, Josephine, Nicastri, Kate A., Schmid, Steven C., Raskopf, William T., Guzei, Ilia A., Fernández, Israel, Schomaker, Jennifer M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062875/
https://ncbi.nlm.nih.gov/pubmed/32152321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15134-x
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