METB-14. DOWN-REGULATION OF ACETATE METABOLISM TOWARDS FATTY ACIDS IN IDH1 MUTANT GLIOMA

Acetate has recently been identified as a major alternative source of nutrients for glioblastoma and brain metastases. After cellular uptake, acetate is converted to acetyl-CoA, a key metabolic intermediate that fuels the TCA cycle and is an essential building block for the biosynthesis of fatty aci...

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Опубликовано в: :Neuro Oncol
Главные авторы: Najac, Chloe, Radoul, Marina, Viswanath, Pavithra, Chaumeil, Myriam M, Ronen, Sabrina
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692264/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.537
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