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METB-11. HYPOXIA INDUCIBLE FACTOR 1α REPROGRAMS CHOLINE AND ETHANOLAMINE PHOSPHOLIPID METABOLISM IN MUTANT IDH1 GLIOMAS
Mutations in isocitrate dehydrogenase 1 (IDH1) drive tumorigenesis in low-grade gliomas and result in production of the oncometabolite 2-hydroxyglutarate (2-HG). 2-HG extensively reprograms cell metabolism, often in a manner atypical relative to wild-type IDH1 gliomas. In particular, compared to nor...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692995/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.535 |
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