Metabolic Reprogramming in Mutant IDH1 Glioma Cells

BACKGROUND: Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while mutant IDH1 catalyzes the conversion of α-ketoglutarate in...

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Udgivet i:PLoS One
Main Authors: Izquierdo-Garcia, Jose L., Viswanath, Pavithra, Eriksson, Pia, Chaumeil, Myriam M., Pieper, Russell O., Phillips, Joanna J., Ronen, Sabrina M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338038/
https://ncbi.nlm.nih.gov/pubmed/25706986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118781
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