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Metabolic Reprogramming in Mutant IDH1 Glioma Cells
BACKGROUND: Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while mutant IDH1 catalyzes the conversion of α-ketoglutarate in...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4338038/ https://ncbi.nlm.nih.gov/pubmed/25706986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118781 |
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