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Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma
Approximately 80% of low-grade glioma (LGGs) harbor mutant isocitrate dehydrogenase 1/2 (IDH1/2) driver mutations leading to accumulation of the oncometabolite 2-hydroxyglutarate (2-HG). Thus, inhibition of mutant IDH is considered a potential therapeutic target. Several mutant IDH inhibitors are cu...
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| Publicado no: | Metabolites |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7917625/ https://ncbi.nlm.nih.gov/pubmed/33668509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11020109 |
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