Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma

Approximately 80% of low-grade glioma (LGGs) harbor mutant isocitrate dehydrogenase 1/2 (IDH1/2) driver mutations leading to accumulation of the oncometabolite 2-hydroxyglutarate (2-HG). Thus, inhibition of mutant IDH is considered a potential therapeutic target. Several mutant IDH inhibitors are cu...

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Dettagli Bibliografici
Pubblicato in:Metabolites
Autori principali: Radoul, Marina, Hong, Donghyun, Gillespie, Anne Marie, Najac, Chloé, Viswanath, Pavithra, Pieper, Russell O., Costello, Joseph F., Luchman, Hema Artee, Ronen, Sabrina M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917625/
https://ncbi.nlm.nih.gov/pubmed/33668509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11020109
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