GENE-46. COMPARISON OF MATCHED GLIOBLASTOMA TUMOR AND MARGIN SAMPLES USING SINGLE BASE RESOLUTION MAPS REVEALS ACQUIRED, EARLY EPIGENETIC CHANGES THAT PREDISPOSE TO MUTATIONS DURING TUMOURIGENESIS

INTRODUCTION: Aberrant genetic and epigenetic changes drive malignant transformation and are hallmarks of cancer. Methylation patterns of 5-methylcytosine (5mC) and its intermediate metabolite 5-hydroxymethylcytosine (5hmC) become aberrant in cancer. These epigenetic changes have been associated wit...

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Publicado no:Neuro Oncol
Main Authors: Raiber, Eun-Ang, Beraldi, Dario, Cuesta, Sergio Martinez, McInroy, Gordon, Kingsbury, Zoya, Becq, Jennifer, James, Terena, Lopes, Margarida, Allinson, Kieren, Field, Sarah, Humphray, Sean, Santarius, Thomas, Watts, Colin, Bentley, David, Balasubramanian, Shankar
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692229/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.419
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