Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma

Aberrant genetic and epigenetic variations drive malignant transformation and are hallmarks of cancer. Using PCR-free sample preparation we achieved the first in-depth whole genome (hydroxyl)-methylcytosine, single-base-resolution maps from a glioblastoma tumour/margin sample of a patient. Our data...

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Vydáno v:NPJ Genom Med
Hlavní autoři: Raiber, Eun-Ang, Beraldi, Dario, Martínez Cuesta, Sergio, McInroy, Gordon R., Kingsbury, Zoya, Becq, Jennifer, James, Terena, Lopes, Margarida, Allinson, Kieren, Field, Sarah, Humphray, Sean, Santarius, Thomas, Watts, Colin, Bentley, David, Balasubramanian, Shankar
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677956/
https://ncbi.nlm.nih.gov/pubmed/29263824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-017-0007-6
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